2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium
1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium
CAS: 34316-15-9
Molecular Formula: C21H18NO4+
2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium - Names and Identifiers
| Name | 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium |
| Synonyms | Cheleritrine Chelerythrine chloride CHELERYTHRINE(TODDALINE)(RG) 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium 1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium 2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |
| CAS | 34316-15-9 |
| EINECS | 251-930-0 |
| InChI | InChI=1/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1 |
2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium - Physico-chemical Properties
| Molecular Formula | C21H18NO4+ |
| Molar Mass | 348.37192 |
| Density | 1.2985 (rough estimate) |
| Melting Point | 195-205°C |
| Boling Point | 496.37°C (rough estimate) |
| Solubility | It is soluble in methanol and ethanol, has a certain solubility in water, and is insoluble in solvents such as petroleum ether and chloroform. |
| Appearance | Pale yellow powder or light white powder |
| Color | Light Yellow to Dark Orange |
| Storage Condition | Desiccate at -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.5614 (estimate) |
| MDL | MFCD00270393 |
| Physical and Chemical Properties | Soluble in methanol, ethanol, water has a certain solubility, insoluble in petroleum ether, chloroform and other solvents. The root and leaf of a plant of Rutaceae, pterostillae (L.)Lam. |
2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium - Reference
| Reference Show more | 1. Zhou Jia, Yang Minghe, Zhou Qixin et al. Effects of Different producing areas and harvest time on the content of effective components in Celandine in Jilin province [J]. Ginseng Research 2020v.32;No.135(01):27-34. 2. Zhou Jia, Xu Jia-ming, Yang Ming Hui, Xu Yan, Zhao Xiaotong, Liu Yunxin, Li Xin, Huang Xiaowei, Tang qiuzhu. Comparison of pharmacodynamics of celandine from different habitats in Jilin province [J]. Chinese Journal of Hospital Pharmacy, 2020, 40(11):1206-1211. 3. Liang Hao, Qian Xiyan, du Xiaojing, Yu Jiansheng. Study on preparation technology of inclusion compound of chymocrine with β-cyclodextrin [J]. Heilongjiang Journal of Animal Science and Veterinary Medicine, 2020, 25 (15):131-134, 176. 4. Han Cong, Zhu Guofu. Study on apoptosis of human hepatocellular carcinoma cell line HepG2 induced by Celandine [J]. Chinese Journal of Experimental prescriptions, 2016, 26 (11):127-130. 5. Zhang Weiwei, Zhu Jifeng, Wang Ren, Gao Yanan, Zhang Junfeng, Yi Shujuan. Resveratrol regulates Th1 and Th2 responses to inhibit liver fibrosis in mice with schistosomiasis japonica [J]. Chinese pharmacological Bulletin (Issue 8):1091-1097. 6. Wang Xiaoli, Guo Lina, Kong Huanyu, etc. Determination of celandine in Celandine in Qiqihar area [J]. Journal of Qiqihar Medical College, 2014(16):2441-2441. 7. Liang Hao, du Xiaojing, Yu Jiansheng, etc. Study on extraction process of alkaloids from Macleaya by internal boiling [J]. Heilongjiang Animal Husbandry and Veterinary (second half month) 2019 000(007):140-142. 8. Lu Yi, Zhu Yuanzhang, Guo Chenxu, etc. Anti-inflammatory and analgesic effects of ethanol extract from Dragon's palm blood [J]. Chinese patent medicine, 2018, 040(001):26-32. 9. Zheng Meixia, Su Hailan, Zhu Yujing. Optimization of extraction process of alkaloids from Macleaya [J]. Journal of Food Safety and quality testing, 2020 011(010):3087-3091. 10. Liang Hao, Qian Xiyan, du Xiaojing, Yu Jiansheng. Study on preparation technology of inclusion compound of chymocrine with β-cyclodextrin [J]. Heilongjiang Journal of Animal Science and Veterinary Medicine, 2020, 25 (15):131-134, 176. 11. Liang Hao, Qian Xiyan, du Xiaojing, Yu Jiansheng. Optimization of extraction technology of celandine by response surface methodology [J]. Northern horticulture, 2020, 38 (19):107-112. 12. Jia Changqing, Ma Rui, Wang Dandan, Qian Xiyan, Yu Jiansheng. Separation and Purification of sanguinarine hydrochloride and chlorhexine hydrochloride from MacLea rubra by recrystallization [J]. Yunnan chemical industry, 2021,48(01):38-41. 13. [IF = 2.233] Yuan Zhang Zhu et al."Chelerythrine inhibitors human hepatocellular carcinoma in vitro." Biological & Pharmaceutical Bulletin. Oct 31 14. [IF = 9.642] Chenman Li et al. Biotransformation of alkylamides and alkaloids by lactic acid bacteria strains isolated from Zanthoxylum bungeanum meal."Bioresource Technol. 2021 Jun;330:124944 15. [IF=3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine."Pestic Biochem Phys. 2019 Sep;159:51 |
2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium - Reference Information
| celandine plant extract | celandine is a celandine plant extract, which is derived from the roots and leaves of the rutaceae plant Feilongzhang blood and the poppy plant celandine A kind of isoquinoline alkaloid extracted and refined from the whole plant with roots. The appearance of the products sold on the market is usually a light yellow to tan solid powder, which is completely soluble in ethanol. It has the effects of clearing away heat and detoxification, antibacterial, anti-inflammatory, antihypertensive and anti-cancer. in vitro can inhibit streptococcus a, cataph, type I nai, nai's mucosa, pneumococcus, haemophilus influenzae and other gram-positive bacteria. It can inhibit Mycobacterium tuberculosis in vivo. Low concentration of chcelandine can inhibit phage and Escherichia coli. |
| biological activity | Chelerythrine is a natural alkaloid, which is an effective and selective Ca2/phospholipid-dependent PKC antagonist with an IC50 value of 0.7 μM. Chelerythrine has anti-tumor, anti-diabetic and anti-inflammatory activities. Chelerythrine inhibited BclXL-Bak BH3 peptide binding, IC50 was 1.5 μM, and Bax was replaced from BclXL. Chelerythrine induces apoptosis and autophagy. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: antibacterial and antibacterial effects, with heat-clearing and detoxification, antibacterial and anti-inflammatory effects. A potent inhibitor of cell-permeable protein kinase C, IC50:660nm. |
Last Update：2024-04-09 21:04:16
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Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Chelerythrine Visit Supplier Webpage Request for quotationCAS: 34316-15-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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